Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2006 Nov;28(5):450-3.
doi: 10.1016/j.ijantimicag.2006.08.017. Epub 2006 Oct 10.

Multi-azole resistance in Aspergillus fumigatus

Susan J Howard  1 , Ian Webster, Caroline B Moore, Rebecca E Gardiner, Steven Park, David S Perlin, David W Denning
Affiliations
Case Reports

Multi-azole resistance in Aspergillus fumigatus

Susan J Howard et al. Int J Antimicrob Agents. 2006 Nov.

Abstract

Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole. A novel mutation (G138C) in the target gene (cyp51A) encoding 14alpha-demethylase was detected. The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources