Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jan 1;15(1):365-73.
doi: 10.1016/j.bmc.2006.09.051. Epub 2006 Oct 10.

Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives

Mi Na Jo  1 , Hee Jeong Seo, Yoonji Kim, Seon Hee Seo, Hyewhon Rhim, Yong Seo Cho, Joo Hwan Cha, Hun Yeong Koh, Hyunah Choo, Ae Nim Pae
Affiliations

Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives

Mi Na Jo et al. Bioorg Med Chem. .

Abstract

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pains. Since the withdrawal of mibefradil, a T-type calcium channel blocker, there have been a lot of efforts to develop T-type calcium channel blockers. A small molecule library of dioxoquinazoline carboxamide derivatives containing 155 compounds was designed, synthesized, and biologically evaluated for T-type calcium channel blocking activity. Among those compounds synthesized, the compound 1n shows the most potent T-type calcium current blocking activity with an IC(50) value of 1.52 microM, which is comparable to that of mibefradil.

PubMed Disclaimer

Publication types

LinkOut - more resources