[Immune hematologic diagnosis in women with habitual abortion]

Abstract

It has been proposed that unexplained recurrent miscarriages are caused by maternal immune rejection of the semi-allogenic fetus. The problem has been treated by immunization with paternal leukocytes to induce maternal antipaternal-antibodies that may block immune rejection of the fetus. It has been suggested that excessive sharing of HLA antigens predisposes couples to recurrent abortion. However, we did not find evidence for excessive HLA-sharing. The degree of sharing did not differ significantly between the couples with recurrent miscarriages and controls with successful pregnancies.