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Review
. 2006 Nov;8(6):430-6.
doi: 10.1007/s11912-006-0071-z.

Induction of apoptosis in lymphoid and myeloid leukemia

Aaron D Schimmer  1
Affiliations
Review

Induction of apoptosis in lymphoid and myeloid leukemia

Aaron D Schimmer. Curr Oncol Rep. 2006 Nov.

Abstract

Defects in the core machinery of the apoptosis pathway contribute to chemoresistance and poor outcomes in patients with acute leukemia. To overcome these defects, novel molecules that target key proteins in the apoptosis pathway are being developed. This review highlights compounds that target the mitochondrial, death receptor, and convergence pathways of caspase activation that are being developed for the treatment of acute leukemia.

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