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Clinical Trial
. 2007 Jan;51(1):379-82.
doi: 10.1128/AAC.00515-06. Epub 2006 Oct 16.

Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains

Ronny Beer  1 , Klaus W Engelhardt, Bettina Pfausler, Gregor Broessner, Raimund Helbok, Peter Lackner, Christian Brenneis, Stefan T Kaehler, Apostolos Georgopoulos, Erich Schmutzhard
Affiliations
Clinical Trial

Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains

Ronny Beer et al. Antimicrob Agents Chemother. 2007 Jan.

Abstract

The pharmacokinetic profile of linezolid in cerebrospinal fluid (CSF) in five neurointensive care patients with staphylococcal ventriculitis was studied. The mean area under concentration-time curve (+/- standard deviation) was 63 +/- 18.9 mg x h/liter, with a CSF-to-plasma ratio of 0.8 +/- 0.3. Times above MIC in CSF were 99.8% and 57.2% for pathogens with MICs of 2 mg/liter and 4 mg/liter, respectively.

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Figures

FIG. 1.
FIG. 1.
Time-concentration curves (means ± SDs) of linezolid in plasma and CSF. (a) Profile after administration of a single intravenous dose of 600 mg (n = 5). (b) Profile after multiple intravenous doses (600 mg twice daily; n = 5). The dotted horizontal lines represent MICs (2 and 4 mg/liter) for susceptible pathogens.
See this image and copyright information in PMC

References

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