Pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem, in healthy male Caucasian volunteers

Abstract

The CS-023 concentration in plasma after administration by infusion to healthy volunteers at a dose of 700 mg was decreased, with a half-life of 1.7 h, and the cumulative urinary excretion was 59.4% of the dose. The total clearance, renal clearance, and volume of distribution were 8.12 liters/h, 4.14 liters/h, and 17.2 liters, respectively.

FIG. 1.

Chemical structure of CS-023.

FIG. 2.

Plasma concentration-time profiles of CS-023 after administration by intravenous infusion for 30 min to healthy male Caucasian volunteers over a dose range of 50 to 2,100 mg. Each point represents the mean ± SD for six volunteers. The plasma concentrations were not detected at 24 h after the start of the infusion in all cases.