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. 2006 Nov;77(11):1279-81.
doi: 10.1136/jnnp.2006.100800.

Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke

A Chamorro  1 , S Amaro, M Vargas, V Obach, A Cervera, F Torres, A M Planas
Affiliations

Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke

A Chamorro et al. J Neurol Neurosurg Psychiatry. 2006 Nov.

Abstract

Background and purpose: The pathophysiology of stroke-associated infection (SAI) is uncertain. The cytokine profile and peripheral white cell response were assessed in patients with or without SAI.

Methods: The incidence of SAI was assessed in 110 patients with ischaemic stroke allocated antibiotic prophylaxis or placebo within 24 h of clinical onset. Peripheral white cell counts, interleukin (IL)6, tumour necrosis factor (TNF)alpha and IL10 were measured in plasma.

Results: 17 (15%) patients developed infection and showed time-dependent increases of total white cell count, neutrophils, monocytes, lymphocytes, IL6 and IL10, whereas TNFalpha and the TNFalpha/IL10 ratio decreased. In logistic regression, IL10 (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.01 to 1.16), monocyte count (OR 1.42, 95% CI 1.08 to 1.87) and National Institute for Health Stroke Survey score on admission (OR 1.17, 95% CI 1.05 to 1.31) were independent predictors of systemic infection.

Conclusions: SAI is associated with stroke severity, excessive IL10-mediated response and an increased number of circulating monocytes. These results support the finding that acute ischaemic brain injury triggers a blood-borne anti-inflammatory response that decreases the antimicrobial drive of the immune system.

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Conflict of interest statement

Competing interests: None.

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