Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Oct;12(8):601-7.
doi: 10.1016/j.cardfail.2006.07.005.

Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study

Joachim H Ix  1 , Michael G Shlipak, Glenn M Chertow, Sadia Ali, Nelson B Schiller, Mary A Whooley
Affiliations

Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study

Joachim H Ix et al. J Card Fail. 2006 Oct.

Abstract

Background: Impaired kidney function, as measured by serum cystatin C, is associated with risk of incident heart failure. Whether cystatin C is associated with preclinical cardiac structural abnormalities is unknown. We evaluate whether cystatin C is associated with left ventricular hypertrophy, diastolic dysfunction, and systolic dysfunction among 818 outpatients with coronary artery disease who were free of clinical heart failure.

Methods and results: The 818 study participants were categorized into quartiles based on serum cystatin C concentrations, with < or =0.91 mg/L constituting the lowest quartile (I) and > or =1.28 mg/L constituting the highest (IV). Left ventricular hypertrophy (left ventricular mass index >90 g/m(2) by truncated ellipsoid method), diastolic dysfunction (impaired relaxation, pseudo-normal, or restrictive filling patterns) and systolic dysfunction (left ventricular ejection fraction < or =50%) were determined by echocardiography. Left ventricular hypertrophy was present in 68% of participants in quartile IV, compared with 44% of those in quartile I (adjusted odds ratio [OR] 2.17; 95% confidence interval [CI] 1.34 to 3.52; P = .002). Diastolic dysfunction was present in 52% of participants in quartile IV, compared with 24% of those in quartile I (adjusted OR 1.79; 95% CI 1.04 to 3.11; P = .04). Systolic dysfunction was present in 12% of those in quartile IV, compared with 6% of those in quartile I (adjusted OR 1.83; 95% CI 0.75 to 4.46; P = .15).

Conclusion: Higher cystatin C concentrations are strongly associated with left ventricular hypertrophy and diastolic dysfunction in outpatients with coronary artery disease and without heart failure.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Proportion with ventricular dysfunction by kidney function quartile groups among persons without heart failure. (A) Left ventricular hypertrophy. (B) Diastolic dysfunction. (C) Systolic dysfunction.
See this image and copyright information in PMC

References

    1. Coll E, Botey A, Alvarez L, Poch E, Quinto L, Saurina A, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000;36:29–34. - PubMed
    1. Gokkusu CA, Ozden TA, Gul H, Yildiz A. Relationship between plasma Cystatin C and creatinine in chronic renal diseases and Tx-transplant patients. Clin Biochem. 2004;37:94–7. - PubMed
    1. Newman DJ, Thakkar H, Edwards RG, Wilkie M, White T, Grubb AO, et al. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int. 1995;47:312–8. - PubMed
    1. Bokenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C—a new marker of glomerular filtration rate in children independent of age and height. Pediatrics. 1998;101:875–81. - PubMed
    1. Fliser D, Ritz E. Serum cystatin C concentration as a marker of renal dysfunction in the elderly. Am J Kidney Dis. 2001;37:79–83. - PubMed

Publication types