doi: 10.1016/j.bmcl.2006.09.066.
Epub 2006 Oct 10.
Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: a semi-empirical investigation
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- PMID: 17045478
- DOI: 10.1016/j.bmcl.2006.09.066
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Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2: a semi-empirical investigation
Bioorg Med Chem Lett.
.
Abstract
A novel phosphate transfer process involving the non-enzymatic transfer of a phosphate group from inositol pyrophosphates to serine residues in proteins has been recently reported. Semi-empirical calculations at the PM3/SM5.2 level were undertaken to explore the effect of inositol pyrophosphate structure and overall charge on the thermodynamics of this phosphate transfer.
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