Exiting the outside world for cross-presentation
- PMID: 17046678
- DOI: 10.1016/j.immuni.2006.09.003
Exiting the outside world for cross-presentation
Abstract
How are extracellular proteins cross-presented on MHC class I molecules? In this issue of Immunity, demonstrate that the ER-associated degradation (ERAD) export pathway operates in the phagosomes of dendritic cells and transfers antigens into the MHC class I pathway.
Comment on
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A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells.Immunity. 2006 Oct;25(4):607-17. doi: 10.1016/j.immuni.2006.08.017. Epub 2006 Oct 5. Immunity. 2006. PMID: 17027300
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