Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Nov;55(5):823-8.
doi: 10.1016/j.jaad.2006.07.015. Epub 2006 Sep 14.

Clinical experience in pemphigoid gestationis: report of 10 cases

Luis A Castro  1 , Ryan B Lundell, Patricia K Krause, Lawrence E Gibson
Affiliations

Clinical experience in pemphigoid gestationis: report of 10 cases

Luis A Castro et al. J Am Acad Dermatol. 2006 Nov.

Abstract

Background: Pemphigoid gestationis is a rare autoimmune blistering disease that occurs during pregnancy.

Objective: This study reviewed our clinical experience with pemphigoid gestationis.

Methods: We reviewed medical records of 10 patients with pemphigoid gestationis seen at Mayo Clinic, Rochester, Minnesota, between 1976 and 2004.

Results: Urticarial papules were the most frequent clinical presentation followed by blisters and rash. Pruritus was the cardinal symptom. Lesions presented initially on the legs, thighs, back, and chest. Direct immunofluorescence had the highest diagnostic test sensitivity. Systemic corticosteroids were the mainstay of treatment. Fetal and maternal outcome was good in all cases.

Limitations: This was a retrospective, single-institution study.

Conclusions: This condition can be easily confused with other dermatoses of pregnancy, for example, pruritic urticarial papules of pregnancy. Biopsy for direct immunofluorescence is the preferred test for confirmation of diagnosis. On the basis of good patient outcomes, conservative treatment seems warranted.

PubMed Disclaimer

Substances