The reaction of ferric- and ferrous salts with bleomycin
- PMID: 1705524
- DOI: 10.1016/0020-711x(91)90196-t
The reaction of ferric- and ferrous salts with bleomycin
Abstract
1. A comparative study shows that ferrous ions give a much better yield of Fe(III)-bleomycin than ferric ions, when iron salt is added to bleomycin in a buffer solution (pH 7.2). 2. The amount of Fe(III)-bleomycin formed after addition of ferric ions was markedly increased in the presence of ferric ion binding compounds (BSA, citrate) or reducing agents (ascorbate, cysteine).