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Comparative Study
. 1991;23(2):235-8.
doi: 10.1016/0020-711x(91)90196-t.

The reaction of ferric- and ferrous salts with bleomycin

Affiliations
Comparative Study

The reaction of ferric- and ferrous salts with bleomycin

R A Løvstad. Int J Biochem. 1991.

Abstract

1. A comparative study shows that ferrous ions give a much better yield of Fe(III)-bleomycin than ferric ions, when iron salt is added to bleomycin in a buffer solution (pH 7.2). 2. The amount of Fe(III)-bleomycin formed after addition of ferric ions was markedly increased in the presence of ferric ion binding compounds (BSA, citrate) or reducing agents (ascorbate, cysteine).

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