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doi: 10.1016/j.cell.2006.10.001.
The complex route to MHC class I-peptide complexes
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- PMID: 17055423
- DOI: 10.1016/j.cell.2006.10.001
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Comment
The complex route to MHC class I-peptide complexes
Cell.
.
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Abstract
The loading of peptides into the groove of MHC class I molecules prior to antigen presentation is a complex process. In this issue of Cell, Park et al. (2006) show that peptide loading gets a helping hand from a resident ER enzyme called protein disulfide isomerase, a chaperone that has oxidoreductase activity.
Comment on
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Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing.Cell. 2006 Oct 20;127(2):369-82. doi: 10.1016/j.cell.2006.08.041. Cell. 2006. PMID: 17055437
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