Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Oct 20;127(2):265-75.
doi: 10.1016/j.cell.2006.10.003.

The regulation of INK4/ARF in cancer and aging

William Y Kim  1 , Norman E Sharpless
Affiliations
Free article
Review

The regulation of INK4/ARF in cancer and aging

William Y Kim et al. Cell. .
Free article

Abstract

Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus--p15(INK4b), p16(INK4a), and ARF--play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p16(INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p16(INK4a), ARF, and p15(INK4b) in cancer and aging.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources