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. 2007 Mar;78(3):315-7.
doi: 10.1136/jnnp.2006.101352. Epub 2006 Oct 20.

Prevalence of haemochromatosis gene mutations in Parkinson's disease

Anne Hege Aamodt  1 , Lars Jacob Stovner, Ketil Thorstensen, Stian Lydersen, Linda R White, Jan O Aasly
Affiliations

Prevalence of haemochromatosis gene mutations in Parkinson's disease

Anne Hege Aamodt et al. J Neurol Neurosurg Psychiatry. 2007 Mar.

Abstract

The aim of this study was to investigate a possible association between haemochromatosis (HFE) gene mutations and the prevalence of Parkinson's disease. The HFE gene encodes a protein that modulates iron absorption. Several studies have documented increased iron levels in the basal ganglia in patients with Parkinson's disease. In a study on patients with concurrent hereditary haemochromatosis and Parkinson's disease, abnormal deposition of iron in the basal ganglia was suggested as an inductor of Parkinson's disease. In this study, genotype frequencies of the HFE mutations C282Y, H63D and S65C were estimated in 388 patients with Parkinson's disease and compared with frequencies found in comparable studies. No significant differences were found in frequencies between the patients and comparable populations. This study does not indicate increased susceptibility to Parkinson's disease in HFE gene mutation carriers in Norway.

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Conflict of interest statement

Competing interests: None.

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