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Review
. 2006 Nov;7(11):867-73.
doi: 10.1038/nrm2043.

The twentieth century struggle to decipher insulin signalling

Philip Cohen  1
Affiliations
Review

The twentieth century struggle to decipher insulin signalling

Philip Cohen. Nat Rev Mol Cell Biol. 2006 Nov.

Abstract

Following the discovery of insulin, it took the rest of the twentieth century to understand how this hormone regulates intracellular metabolism. What are the main discoveries that led to our current understanding of this process? And how is this new knowledge being exploited in an attempt to develop improved drugs to treat the epidemic of type-2 diabetes?

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