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. 2006 Jul;29(7):689-91.

[Studies on active substance of anticancer effect in Polygonum cuspidatum]

[Article in Chinese]
Lei Feng  1 , Lian-fen Zhang, Ting Yan, Jian Jin, Wen-yi Tao
Affiliations
  • PMID: 17059010

[Studies on active substance of anticancer effect in Polygonum cuspidatum]

[Article in Chinese]
Lei Feng et al. Zhong Yao Cai. 2006 Jul.

Abstract

Objective: To supply the scientific basis of research and development of the medicinal value of Polygonum cuspidatum.

Methods: One composition was isolated from the roots of Polygonum cuspidatum by cytotoxicity based fractionation and identified by HPLC-MS, UV scanning and IR. The inhibition and morphology of L-02, Hep G2, SHZ-888, MCF-7, MCF-7/ADM cells growth caused by this composition was determined by MTT assay and HE dyeing.

Results: This composition was identified as trans-and cis-resveratrol. It could specifically inhibit proliferation of many cancer cells but not human normal liver cell. We investigated the cytotoxicity of resveratrol to adriamycin-resistant MCF-7 cell in virtro.

Conclusion: Resveratrol is a new anticancer composition which is less toxicity and higher efficiency in Polygonum cuspidatum.

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