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. 1975 Jul;72(7):2563-7.
doi: 10.1073/pnas.72.7.2563.

Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40

G Khoury, P M Howley, C Garon, M F Mullarkey, K K Takemoto, M A Martin

Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40

G Khoury et al. Proc Natl Acad Sci U S A. 1975 Jul.

Abstract

A number of hybridization techniques have been used to assess the homology between the genomes of BK virus (BKV) and simian virus 40 (SV40). A noncontiguous set of homologous sequences has been localized primarily within the late region of the SV40 genome, and these sequences presumably account for the cross-reaction between V-antigens of the two viruses. The reason for the relatively strong crossreaction between SV40 and BKV T-antigens is still unclear. The sequence homology and similarity in genomic organization suggest a close relationship between these papovaviruses.

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References

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