Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Aug;41(8):e10; discussion e10.
doi: 10.1136/bjsm.2006.030643. Epub 2006 Oct 24.

Tissue engineering for tendon repair

Pierre-Olivier Bagnaninchi  1 , Ying Yang, Alicia J El Haj, Nicola Maffulli
Affiliations
Review

Tissue engineering for tendon repair

Pierre-Olivier Bagnaninchi et al. Br J Sports Med. 2007 Aug.

Abstract

Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

    1. Takakuda K, Miyairi H. Tensile behaviour of fibroblasts cultured in collagen gel. Biomaterials 1996171393–1397. - PubMed
    1. Grinnell F. Fibroblast biology in three‐dimensional collagen matrices. Trends Cell Biol 200313264–269. - PubMed
    1. Lamberti P M, Wezeman F H. Biologic behavior of an in vitro hydrated collagen gel‐human tenocyte tendon model. Clin Orthop Relat Res 2002397414–423. - PubMed
    1. Noth U, Schupp K, Heymer A.et al Anterior cruciate ligament constructs fabricated from human mesenchymal stem cells in a collagen type I hydrogel. Cytotherapy 20057447–455. - PubMed
    1. Young R G, Butler D L, Weber W.et al Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair. J Orthop Res 199816406–413. - PubMed

Publication types

Substances