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. 2006 Nov;155(5):645-53.
doi: 10.1530/eje.1.02289.

RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture

Massimo Santoro  1 , Rosa Marina Melillo, Alfredo Fusco
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RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture

Massimo Santoro et al. Eur J Endocrinol. 2006 Nov.

Abstract

Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.

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