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. 2006 Dec;78(12):1584-7.
doi: 10.1002/jmv.20742.

Detection of herpes simplex virus type 1 DNA in bilateral human trigeminal ganglia and optic nerves by polymerase chain reaction

Hisako Motani  1 , Koichi Sakurada, Hiroshi Ikegaya, Tomoko Akutsu, Mutsumi Hayakawa, Yayoi Sato, Daisuke Yajima, Kaoru Sato, Kazuhiro Kobayashi, Hirotaro Iwase
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Detection of herpes simplex virus type 1 DNA in bilateral human trigeminal ganglia and optic nerves by polymerase chain reaction

Hisako Motani et al. J Med Virol. 2006 Dec.

Abstract

Herpes simplex virus type 1 (HSV-1) DNA was extracted from human trigeminal ganglia of 121 cadavers aged between 3 months and 94 years, and its PCR amplification was performed for the RL2 HSV-1 sequence using two pairs of primers. The HSV-1 DNA was detected in 74 of 121 patients (61%); 70/74 bilaterally, 3/74 only on the left side, and 1/74 only on the right side. Although the PCR-positive rate was significantly higher in advanced age, the correlation between the PCR-positive rate and gender was unclear. Additionally, HSV-1 DNA was not detected in any of the 50 optic nerve samples.

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