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. 2006 Dec;54 Suppl 2(Suppl 2):S3-7.
doi: 10.1016/j.lungcan.2006.09.014. Epub 2006 Oct 24.

Pharmacogenomics: a reality or still a promise?

Gerold Bepler  1
Affiliations

Pharmacogenomics: a reality or still a promise?

Gerold Bepler. Lung Cancer. 2006 Dec.

Abstract

Although notable progress has been made in the treatment of non-small-cell lung cancer (NSCLC) in recent years, this disease is still associated with a poor prognosis for most patients. Modern techniques have facilitated the identification of specific genetic factors that may play a role in disease progression and patient response to therapy, prompting research efforts to identify the clinical predictors of outcome for NSCLC. Recent evidence suggests that the application of a pharmacogenomic approach has the potential to greatly improve survival in certain subpopulations of patients with NSCLC, which could profoundly influence the decision-making process used in evolving treatment strategies for this malignancy.

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Figures

Figure 1
Figure 1
Effect of RRM1 levels on gemcitabine in vitro.
Figure 2
Figure 2
Effect of RRM1 levels on carboplatin in vitro.
Figure 3
Figure 3
Study design for the MCC-13208 (MADeIT) trial.
See this image and copyright information in PMC

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References

    1. Rouet P, Smih F, Jasin M. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol Cell Biol. 1994;14:8096–8106. - PMC - PubMed
    1. Liang F, Han M, Romanienko PJ, Jasin M. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc Natl Acad Sci USA. 1998;95:5172–5177. - PMC - PubMed
    1. Bepler G, Gautam A, McIntyre LM, Beck AF, Chervinsky DS, et al. Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in non-small-cell lung cancer. J Clin Oncol. 2002;20:1353–1360. - PubMed
    1. Pitterle DM, Jolicoeur EC, Bepler G. Hot spots for molecular genetic alterations in lung cancer. In Vivo. 1998;12:643–658. - PubMed
    1. Bepler G, Garcia-Blanco MA. Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer. Proc Natl Acad Sci USA. 1994;91:5513–5517. - PMC - PubMed

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