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. 1990;107(3-4):88-92.
doi: 10.1007/BF01405785.

Acidic fibroblast growth factor (aFGF) is present in the fluid of brain tumour pseudocysts

J R Moringlane  1 , R Spinas, P Böhlen
Affiliations

Acidic fibroblast growth factor (aFGF) is present in the fluid of brain tumour pseudocysts

J R Moringlane et al. Acta Neurochir (Wien). 1990.

Abstract

Fluid samples from brain tumour pseudocysts were examined for the presence of Fibroblast Growth Factor (FGF). Fluids were collected from 6 patients with differentiated low grade gliomas (group A), 3 anaplastic gliomas (group B) and 3 metastases (group C). For FGF assays pooled fluids from group A, B, and C were subjected to affinity chromatography on a Heparin-Sepharose column. Each pool contained endothelial cell mitogenic activity which eluted in the 1.2 M NaCl fraction and to a lesser degree in the 0.6 M fraction of Heparin-Sepharose high affinity chromatography. Mitogenic activity in the 1.2 M NaCl fraction of Heparin-Sepharose chromatography suggests the presence of acidic FGF (aFGF).

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