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Multicenter Study
. 2007 Apr 5;144B(3):361-4.
doi: 10.1002/ajmg.b.30431.

Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene

Gary A Heiman  1 , Ruth Ottman, Rachel J Saunders-Pullman, Laurie J Ozelius, Neil J Risch, Susan B Bressman
Affiliations
Multicenter Study

Obsessive-compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene

Gary A Heiman et al. Am J Med Genet B Neuropsychiatr Genet. .

Abstract

Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are co-morbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia.

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