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. 2006 Oct 27;314(5799):645-7.
doi: 10.1126/science.1135213.

Functional CpG methylation system in a social insect

Ying Wang  1 , Mireia Jorda, Peter L Jones, Ryszard Maleszka, Xu Ling, Hugh M Robertson, Craig A Mizzen, Miguel A Peinado, Gene E Robinson
Affiliations

Functional CpG methylation system in a social insect

Ying Wang et al. Science. .

Abstract

DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.

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