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Review
. 2006 Oct 25;26(43):10935-6; discussion 10936.
doi: 10.1523/jneurosci.3694-06.2006.

Reconsolidation: does the past linger on?

Daniel Fulton  1
Affiliations
Review

Reconsolidation: does the past linger on?

Daniel Fulton. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Training-related NO–cGMP signaling, in the CNS of Lymnaea, may play a role in mediating time-limited activation of PKA after recall. In the model shown here, CS presentation 6 h after conditioning enhances PKA activation through an interaction with training-stimulated cGMP/PKG. After conditioning, NO signaling diminishes with time (filled triangle in bottom box) so that by 24 h, recall is no longer able to activate PKA. Pharmacological inhibitors, such as 1H-(1,2,4)oxadiazole(4,3-a)quinoxalin-1-one (ODQ) and KT5823, as shown (top box), could be used to test the role of cGMP and PKG signaling in memory reconsolidation. US, Unconditioned stimulus.
See this image and copyright information in PMC

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