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Case Reports
. 2006 Oct;133(10):781-3.
doi: 10.1016/s0151-9638(06)71043-2.

[Nicorandil-associated anal ulceration]

[Article in French]
A-L Rival  1 , C Allombert-Blaise, A Ly, J-P Grandjean, M Faure, A Claudy
Affiliations
Case Reports

[Nicorandil-associated anal ulceration]

[Article in French]
A-L Rival et al. Ann Dermatol Venereol. 2006 Oct.

Abstract

Background: Nicorandil is a potassium-channel activator used in the treatment of angina pectoris. The first cases of anal ulcerations induced by nicorandil were published in 2002.

Case report: A 71-year-old man presented with a 2-year history of anal ulcerations occurring within a few months of initiation of treatment with Nicorandil. Histological tests on a biopsy sample showed granulation tissue with non-specific chronic inflammation. Nicorandil was stopped and this resulted in complete healing of the ulcers after three months.

Discussion: Nicorandil can induce chronic and extensive anal ulcerations. The pathogenesis is unknown. Patients are usually treated with high doses of nicorandil. Dermatologists should be aware of this rare side-effect which heals after withdrawal of the drug.

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