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. 2006 Nov;12(11):1253-5.
doi: 10.1038/nm1501. Epub 2006 Oct 29.

Identification of a hormonal basis for gallbladder filling

Mihwa Choi  1 , Antonio Moschetta, Angie L Bookout, Li Peng, Michihisa Umetani, Sam R Holmstrom, Kelly Suino-Powell, H Eric Xu, James A Richardson, Robert D Gerard, David J Mangelsdorf, Steven A Kliewer
Affiliations

Identification of a hormonal basis for gallbladder filling

Mihwa Choi et al. Nat Med. 2006 Nov.

Abstract

The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-15, a hormone made by the distal small intestine in response to bile acids, is required for gallbladder filling. These studies demonstrate that gallbladder filling is actively regulated by an endocrine pathway and suggest a postprandial timing mechanism that controls gallbladder motility.

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