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Review
. 2007 Oct;22(10):1703-10.
doi: 10.1007/s00467-006-0269-1. Epub 2006 Oct 27.

The central nervous system in childhood chronic kidney disease

Debbie S Gipson  1 , Peter J Duquette, Phil F Icard, Stephen R Hooper
Affiliations
Review

The central nervous system in childhood chronic kidney disease

Debbie S Gipson et al. Pediatr Nephrol. 2007 Oct.

Abstract

Neurodevelopmental deficits in pediatric and adult survivors of childhood onset chronic kidney disease (CKD) have been documented for many years. This paper reviews the available literature on central nervous system involvement incurred in childhood CKD. The studies reviewed include recent work in neuroimaging, electrophysiology, and neuropsychology, along with commentary on school functioning and long-term outcomes. The paper concludes with suggestions for monitoring the neurodevelopmental status and pursuing appropriate early interventions for children with CKD.

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Figures

Fig. 1
Fig. 1
Plot of relationship between EEG slowing and serum creatinine. EEG frequency is defined as the number of slow waves (3–7 Hz) divided by the total waves (3–13 Hz), expressed as percent. (Reprinted from [11] with kind permission from Macmillan Publishers)
See this image and copyright information in PMC

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