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Review
. 2006 Nov;36(11):2844-8.
doi: 10.1002/eji.200636760.

Anti-cytokine vaccines and the immunotherapy of autoimmune diseases

David C Wraith  1
Affiliations
Review

Anti-cytokine vaccines and the immunotherapy of autoimmune diseases

David C Wraith. Eur J Immunol. 2006 Nov.

Abstract

Three papers in this issue of the European Journal of Immunology describe the use of cytokine vaccines to prevent autoimmune disease in experimental animals. The vaccines are based on interleukin 17 (IL-17), a cytokine that has recently been shown to play a central role in inflammation.

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Figures

Figure 1
Figure 1
Differentiation of Th17 cells is supported by TGF-β, IL-6, TNF and IL-1 while IL-23 is required for their expansion and survival. Th17 cells secrete IL-17 and their major function is to enhance neutrophil mobilisation. IL-17 is required for effective immunity against specific bacterial and fungal infections in mice. Th17 cells contribute to autoimmune disease in certain models and can either increase or reduce immunity to cancer.
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Comment on

References

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