Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Sep;12(9):1440-3.
doi: 10.3201/eid1209.041068.

Hepatitis C virus genotype 4 in Ugandan children and their mothers

Robert J Biggar  1 , Betty A Ortiz-Conde, Rachel K Bagni, Paul M Bakaki, Cheng-Dian Wang, Eric A Engels, Sam M Mbulaiteye, Christopher M Ndugwa
Affiliations

Hepatitis C virus genotype 4 in Ugandan children and their mothers

Robert J Biggar et al. Emerg Infect Dis. 2006 Sep.

Abstract

In Kampala, Uganda, in 2001, hepatitis C virus antibodies were found in 27 (4%) of 603 children and in 62 (12%) of 525 of their mothers. However, only approximately 10% of positive results were confirmed by reverse transcription-PCR, which suggests frequent false-positive results or viral clearance. All sequenced types were genotype 4.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Estimated phylogenies of hepatitis C virus genotype 4; NS5B phylogenetic analysis based on 350 bp of NS5B nucleotide sequence. Ugandan sequences determined in this study are highlighted in black. Numerical values (presented when >60%) represent the statistical support for the tree topology as determined by 1,000 bootstrap replicates. Reference sequences for genotypes 1–3, 5, and 6 (7) were included in both analyses and retained as the outgroup. Accession numbers are provided in the text.
Figure 2
Figure 2
Estimated phylogenies of hepatitis C virus genotype 4; Core/E1 phylogenetic analysis based on 340 bp spanning the junction between the Core and E1 regions. Ugandan sequences determined in this study are highlighted in black. Numerical values (presented when >60%) represent the statistical support for the tree topology as determined by 1,000 bootstrap replicates. Reference sequences for genotypes 1–3, 5, and 6 (7) were included in both analyses and retained as the outgroup. Accession numbers are provided in the text.
See this image and copyright information in PMC

References

    1. Madhava V, Burgess C, Drucker E. Epidemiology of chronic hepatitis C virus infection in sub-Saharan Africa. Lancet Infect Dis. 2002;2:293–302. 10.1016/S1473-3099(02)00264-5 - DOI - PubMed
    1. Callahan JD, Constantine NT, Kataaha P, Zhang X, Hyams KC, Bansal J. Second generation hepatitis C virus assays: performance when testing African sera. J Med Virol. 1993;41:35–8. 10.1002/jmv.1890410108 - DOI - PubMed
    1. Tess BH, Levin A, Brubaker G, Shao J, Drummond JE, Alter HJ, et al. Seroprevalence of HCV in the general population of northeast Tanzania. Am J Trop Med Hyg. 2000;62:138–41. - PubMed
    1. Jackson JB, Guay L, Goldfarb J, Olness K, Ndugwa C, Mmiro F, et al. Hepatitis C virus antibody in HIV-1 infected Ugandan mothers. Lancet. 1991;337:551. 10.1016/0140-6736(91)91334-Q - DOI - PubMed
    1. Mbulaiteye SM, Biggar RJ, Bakaki PM, Pfeiffer R, Whitby D, Ower AM, et al. Human herpesvirus 8 infection and transfusion history in children with sickle cell disease in Uganda. J Natl Cancer Inst. 2003;95:1330–5. 10.1093/jnci/djg039 - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources