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. 1975 Sep 11;18(4):263-71.
doi: 10.1007/BF02889252.

Distribution of cytoplasmic vacuoles in blood T and B lymphocytes in two lysosomal disorders

P Aula, J Rapola, L C Andersson

Distribution of cytoplasmic vacuoles in blood T and B lymphocytes in two lysosomal disorders

P Aula et al. Virchows Arch B Cell Pathol. .

Abstract

Distribution of cytoplasmic vacuoles in purified T and B lymphocytes was analyzed in four cases of aspartylglucosaminuria (AGU) and in one case of neuronal ceroid lipofuscinosis (Spielmeyer-Sjörgren type). In all cases T cells were significantly more vacuolized than B cells. The ultrastructure of the cytoplasmic vacuoles was consistent with the concept of storage lysosomes. The cytoplasmic vacuoles both in T and B cells similar to abnormal lysosomes seen in the visceral organs in these diseases.

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