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Review
. 2006 Oct;6(10):1169-77.
doi: 10.2174/138955706778560120.

Silicon switches of marketed drugs

P K Pooni  1 , G A Showell
Affiliations
Review

Silicon switches of marketed drugs

P K Pooni et al. Mini Rev Med Chem. 2006 Oct.

Abstract

The application of organosilicon chemistry is a strategy to develop best in class drugs applied to targets that have been validated as tractable and drug-able. Silicon switches of known drugs have been synthesised and evaluated in biological assay systems then compared to their marketed all-carbon counterparts. Recent examples include the silicon switches of drugs haloperidol, fexofenadine, bexarotene and venlafaxine.

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