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. 2006 Oct 30:1:39.
doi: 10.1186/1746-1596-1-39.

Chondrosarcoma of the spine: a rare case with unusual presentation

John Panelos  1 , Spyridon Voulgaris, Evangelos Michos, Michael Doukas, Konstantinos Charalabopoulos, Anna Batistatou
Affiliations

Chondrosarcoma of the spine: a rare case with unusual presentation

John Panelos et al. Diagn Pathol. .

Abstract

Chondrosarcoma is the third most common primary malignancy of bone, affecting primarily the pelvic and shoulder girdles and being extremely rare in the spine. Herein, we present a case of a 65-year-old woman with a rare chondrosarcoma of the spine, who presented with clinical symptoms from the lung metastasis. The neoplasm was grade II and exhibited overexpression of the p53 tumor suppressor protein. The latter has been associated with a high propensity for distant metastases.

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Figures

Figure 1
Figure 1
Multilobular neoplasm with chondroid matrix and nuclear pleiomorphism (haematoxylin and eosin X400).
Figure 2
Figure 2
Increased nuclear immunoreactivity for p53 (DABX400).
Figure 3
Figure 3
Rare nuclear immunoreactivity for MIB-1 (ki-67) (DABX400).
See this image and copyright information in PMC

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