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. 2007 Mar 15;359(2):295-301.
doi: 10.1016/j.virol.2006.09.019. Epub 2006 Oct 30.

Extensive cross-reactive neutralizing antibody response in Indian patients with limited genetic diversity of HIV-1

Samir K Lakhashe  1 , Smita S Kulkarni, Madhuri R Thakar, Manisha V Ghate, Ramesh S Paranjape
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Free article

Extensive cross-reactive neutralizing antibody response in Indian patients with limited genetic diversity of HIV-1

Samir K Lakhashe et al. Virology. .
Free article

Abstract

Genome sequence analysis of HIV-1 subtype C viruses from India shows monophyletic lineage and relatively limited genetic diversity. To understand its immunological implication, cross-reactivity of neutralizing antibody response was investigated. In primary screening, neutralizing antibody response to single heterologous primary HIV-1 subtype C isolate was assessed in plasma samples from 235 HIV-1 infected, anti-retroviral treatment naive individuals from Pune, India. Plasma samples that showed > or =90% neutralization and two randomly selected plasma samples that showed 50-60% neutralization were tested against a panel of primary HIV-1 subtype C isolates obtained from epidemiologically unlinked individuals from India. The neutralizing antibody response showed extensive cross-neutralization, suggesting presence of shared neutralization determinants among circulating HIV-1 subtype C viruses in India.

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