Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2006 Nov;128(5):491-3.
doi: 10.1085/jgp.200609676.

Why pain gets worse: the mechanism of heat hyperalgesia

Affiliations
Comment

Why pain gets worse: the mechanism of heat hyperalgesia

Xuming Zhang et al. J Gen Physiol. 2006 Nov.
No abstract available

PubMed Disclaimer

Comment on

References

    1. Bhave, G., W. Zhu, H. Wang, D.J. Brasier, G.S. Oxford, and R.W. Gereau. 2002. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron. 35:721–731. - PubMed
    1. Bhave, G., H.J. Hu, K.S. Glauner, W. Zhu, H. Wang, D.J. Brasier, G.S. Oxford, and R.W. Gereau. 2003. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc. Natl. Acad. Sci. USA. 100:12480–12485. - PMC - PubMed
    1. Bonnington, J.K., and P.A. McNaughton. 2003. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J. Physiol. 551:433–446. - PMC - PubMed
    1. Bron, R., L.J. Klesse, K. Shah, L.F. Parada, and J. Winter. 2003. Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol. Cell. Neurosci. 22:118–132. - PubMed
    1. Caterina, M.J., M.A. Schumacher, M. Tominaga, T.A. Rosen, J.D. Levine, and D. Julius. 1997. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 389:816–824. - PubMed

MeSH terms