Why pain gets worse: the mechanism of heat hyperalgesia
- PMID: 17074974
- PMCID: PMC2151587
- DOI: 10.1085/jgp.200609676
Why pain gets worse: the mechanism of heat hyperalgesia
Comment on
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Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane.J Gen Physiol. 2006 Nov;128(5):509-22. doi: 10.1085/jgp.200609576. J Gen Physiol. 2006. PMID: 17074976 Free PMC article.
References
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- Bron, R., L.J. Klesse, K. Shah, L.F. Parada, and J. Winter. 2003. Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol. Cell. Neurosci. 22:118–132. - PubMed
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- Caterina, M.J., M.A. Schumacher, M. Tominaga, T.A. Rosen, J.D. Levine, and D. Julius. 1997. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 389:816–824. - PubMed
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