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Review
. 1990;48(3):381-95.
doi: 10.1016/0163-7258(90)90056-8.

Metabolism and mechanism of action of 5-fluorouracil

W B Parker  1 , Y C Cheng
Affiliations
Review

Metabolism and mechanism of action of 5-fluorouracil

W B Parker et al. Pharmacol Ther. 1990.

Abstract

This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA, thymidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5,10-methylene tetrahydrofolate, FUTP.

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