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. 2006 Nov 8;128(44):14264-5.
doi: 10.1021/ja0657859.

Kinetic resolutions of indolines by a nonenzymatic acylation catalyst

Forrest O Arp  1 , Gregory C Fu
Affiliations

Kinetic resolutions of indolines by a nonenzymatic acylation catalyst

Forrest O Arp et al. J Am Chem Soc. .

Abstract

The first method for the kinetic resolution of indolines through catalytic N-acylation is described. To improve the selectivity factor, new planar-chiral PPY-derived catalysts were synthesized, wherein the chiral environment was systematically modified. This work provides a rare example of a nonenzyme-based acylation catalyst for the kinetic resolution of amines.

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References

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