doi: 10.1093/intimm/2.6.539.
Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity
Affiliations
- PMID: 1707660
- DOI: 10.1093/intimm/2.6.539
Item in Clipboard
Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity
Int Immunol.
1990.
Abstract
Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 cells and their capacity to induce paralysis, the clinical hallmark of experimental allergic encephalomyelitis (EAE). No correlation was found between interleukin-2 or gamma interferon production and encephalitogenicity. LT and/or TNF-alpha may play a central role in the pathogenesis of EAE.
Similar articles
-
[Experimental allergic encephalomyelitis: immunopathological analysis of antigenic reactivity and loss of encephalitogenicity].Hokkaido Igaku Zasshi. 1992 Sep;67(5):623-37. Hokkaido Igaku Zasshi. 1992. PMID: 1385288 Japanese.
-
Lymphokine production by encephalitogenic and non-encephalitogenic T-cell clones reactive to the same antigenic determinant.J Neuroimmunol. 1990 Nov;30(1):71-9. doi: 10.1016/0165-5728(90)90054-q. J Neuroimmunol. 1990. PMID: 1699973
-
Production of tumor necrosis factor-alpha as a result of glia-T-cell interaction correlates with the pathogenic activity of myelin basic protein-reactive T cells in experimental autoimmune encephalomyelitis.J Neurosci Res. 1996 Aug 15;45(4):400-9. doi: 10.1002/(SICI)1097-4547(19960815)45:4<400::AID-JNR9>3.0.CO;2-D. J Neurosci Res. 1996. PMID: 8872900
-
Evidence that Fas and FasL contribute to the pathogenesis of experimental autoimmune encephalomyelitis.Arch Immunol Ther Exp (Warsz). 2000;48(5):381-8. Arch Immunol Ther Exp (Warsz). 2000. PMID: 11140465 Review.
-
Myelin specific, autoaggressive T cell clones in the normal immune repertoire: their nature and their regulation.Int Rev Immunol. 1992;9(3):231-41. doi: 10.3109/08830189209061793. Int Rev Immunol. 1992. PMID: 1285063 Review. No abstract available.
Cited by
-
Experimental autoimmune encephalomyelitis: cytokines, effector T cells, and antigen-presenting cells in a prototypical Th1-mediated autoimmune disease.Curr Allergy Asthma Rep. 2003 Jan;3(1):86-93. doi: 10.1007/s11882-003-0017-6. Curr Allergy Asthma Rep. 2003. PMID: 12543000 Review.
-
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.J Clin Invest. 2001 Sep;108(5):739-47. doi: 10.1172/JCI12563. J Clin Invest. 2001. PMID: 11544280 Free PMC article.
-
Oral tolerization with cardiac myosin peptide (614-629) ameliorates experimental autoimmune myocarditis: role of STAT 6 genes in BALB/CJ mice.J Clin Immunol. 2009 Jul;29(4):434-43. doi: 10.1007/s10875-009-9290-z. Epub 2009 Apr 8. J Clin Immunol. 2009. PMID: 19353248
-
B7-mediated costimulation can either provoke or prevent clinical manifestations of experimental allergic encephalomyelitis.Immunol Res. 1995;14(3):189-99. doi: 10.1007/BF02918216. Immunol Res. 1995. PMID: 8778209 Review.
-
Tolerance induction and autoimmune encephalomyelitis amelioration after administration of myelin basic protein-derived peptide.J Exp Med. 1997 Aug 18;186(4):507-15. doi: 10.1084/jem.186.4.507. J Exp Med. 1997. PMID: 9254649 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
