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. 2006 Nov;5(11):996-9.
doi: 10.1039/b606117f. Epub 2006 Oct 9.

Synthesis of estradiol-pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells

Naram El-Akra  1 , Arielle Noirot, Jean-Charles Faye, Jean-Pierre Souchard
Affiliations

Synthesis of estradiol-pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells

Naram El-Akra et al. Photochem Photobiol Sci. 2006 Nov.

Abstract

The synthesis, physico-chemical properties, cellular localization and photocytotoxicity of estradiol-pheophorbide a conjugates in estrogen-dependent cancer and vascular endothelial cells are described with the aim of increasing the photodynamic activity by targeting the nucleus of both tumor and blood vessel cells.

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