Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Oct;47(10):993-8.

Clinical characteristics and predictors of mortality for Cryptococcus gattii infection in dogs and cats of southwestern British Columbia

Colleen Duncan  1 , Craig Stephen, John Campbell
Affiliations

Clinical characteristics and predictors of mortality for Cryptococcus gattii infection in dogs and cats of southwestern British Columbia

Colleen Duncan et al. Can Vet J. 2006 Oct.

Abstract
in English, French

Since 1999, Cryptococcus gattii has emerged as an important pathogen of humans and animals in southwestern British Columbia. Historically thought to be restricted to the tropics and subtropics, C. gattii has posed new diagnostic and treatment challenges to veterinary practitioners working within the recently identified endemic region. Clinical reports of canine and feline cryptococcosis caused by C. gattii diagnosed between January 1999 and December 2003 were included in this case series. The most common manifestations of disease were respiratory and central nervous system signs. Multivariate survival analysis revealed that the only significant predictor of mortality was the presence of central nervous system signs upon presentation or during therapy. Case fatality rates in both species were high. Further investigation into effective treatment regimes is warranted.

Caractéristiques cliniques et prédicteurs de mortalité lors d’infections à Cryptococcus gattii chez des chiens et des chats du sud ouest de la Colombie Britannique. Depuis 1999, Cryptococcus gattii est devenu un pathogène important tant chez les humains que chez les animaux du sud ouest de la Colombie Britannique. Historiquement reconnu pour être localisé en zones tropicales et subtropicales, C. gattii a posé de nouveaux défis diagnostiques et thérapeutiques aux vétérinaires pra‐ticiens travaillant dans cette région identifiée récemment comme endémique. Les rapports cliniques de cryptococcoses causées par C. gattii diagnostiquées entre janvier 1999 et décembre 2003 sont compris dans cette série de cas. Les principaux symptômes de la maladie concernaient les systèmes respiratoire et nerveux central. Une analyse de survie multifactorielle a révélé que le seul prédicteur important de mortalité était la présence de signes du système nerveux central à la présentation ou au cours du traite‐ment. Les taux de mortalité étaient élevés chez les 2 espèces. De futures recherches pour de meilleurs traitements sont nécessaires

(Traduit par Docteur André Blouin)

PubMed Disclaimer

Figures

Figure 1
Figure 1
Cumulative survival for cats and dogs combines with and without central nervous system (CNS) signs.
See this image and copyright information in PMC

References

    1. Sorrell TC. Cryptococcus neoformans variety gattii. Med Mycol. 2001;39:155–168. - PubMed
    1. Kwon‐Chung KJ, Wickes BL, Stockman L, Roberts GD, Ellis D, Howard DH. Virulence, serotype, and molecular characteristics of environmental strains of Cryptococcus neoformans var. gattii. Infect Immun. 1992;60:1869–1874. - PMC - PubMed
    1. Kwon‐Chung KJ, Polacheck I, Bennett JE. Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (serotypes A and D) and Cryptococcus neoformans var. gattii (sero‐types B and C) J Clin Microbiol. 1982;15:535–537. - PMC - PubMed
    1. Katsu M, Kidd S, Ando A, et al. The internal transcribed spacers and 5.8S rRNA gene show extensive diversity among isolates of the Cryptococcus neoformans species complex. FEMS Yeast Res. 2004;4:377–388. - PubMed
    1. Kwon‐Chung J, Boekhout T, Fell J, Diaz M. Proposal to conserve the name Cryptococcus gattii against C. hondurianus and C. bacillisporus (Basidiomycota, Hymenomycetes, Tremellomycetidae) Taxon. 2002;51:804–806.

Publication types

MeSH terms

Substances

LinkOut - more resources