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Review
. 2006 Oct;8(5):446-54.

Progress towards the clinical application of helper-dependent adenoviral vectors for liver and lung gene therapy

Nicola Brunetti-Pierri  1 , Philip Ng
Affiliations
  • PMID: 17078387
Review

Progress towards the clinical application of helper-dependent adenoviral vectors for liver and lung gene therapy

Nicola Brunetti-Pierri et al. Curr Opin Mol Ther. 2006 Oct.

Abstract

This review focuses on recent developments in helper-dependent adenoviral technology and preclinical studies for helper-dependent adenovirus-mediated liver- and lung-directed gene therapy. Studies highlighting the tremendous potential of these vectors are reviewed, together with some important obstacles that will need to be addressed before clinical utility.

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