Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jan;59(1):122-4.
doi: 10.1093/jac/dkl451. Epub 2006 Oct 31.

Effect of caspofungin on trophozoites and cysts of three species of Acanthamoeba

Sabrina Bouyer  1 , Christine Imbert, Gyslaine Daniault, Estelle Cateau, Marie-Hélène Rodier
Affiliations

Effect of caspofungin on trophozoites and cysts of three species of Acanthamoeba

Sabrina Bouyer et al. J Antimicrob Chemother. 2007 Jan.

Abstract

Objectives: Amoebic keratitis is difficult to treat, without total efficacy in some patients because of cysts that are less susceptible than trophozoites to the usual treatments. We investigated here the in vitro effectiveness of caspofungin, a new antifungal, against three species of Acanthamoeba.

Methods: Trophozoites and cysts of Acanthamoeba castellanii, Acanthamoeba culbertsoni and Acanthamoeba polyphaga were incubated with caspofungin at concentrations varying from 16 to 500 mg/L.

Results: The trophozoites of the three tested species were susceptible in vitro to caspofungin at a concentration of 250 mg/L (206 microM). Furthermore, this drug was cysticidal at a concentration of 500 mg/L (412 microM) against A. castellanii and A. culbertsoni.

Conclusions: Caspofungin could represent, if in vivo studies confirm its efficacy, a new anti-Acanthamoeba compound.

PubMed Disclaimer

LinkOut - more resources