Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Dec 19;361(1):61-4.
doi: 10.1007/BF00587340.

H+ transport and membrane-bound HCO - 3 ATPase in salivary duct epithelium

U Wais, H Knauf

H+ transport and membrane-bound HCO - 3 ATPase in salivary duct epithelium

U Wais et al. Pflugers Arch. .

Abstract

An ATPase stimulated by HCO - ions and other oxybases and inhibited by SCN- has been found in main excretory duct of rat submaxillary gland, a tissue, capable of actively secreting HCO - 3 ions. No such ATPase was found in the rabbit duct, which normally does not secrete HCO - 3. The HCO - 3 ATPase was localized in the plasma membrane fraction of the homogenate, as evidenced by the marker 5'-nucleotidase. The activities of the HCO - 3 ATPase increased in metabolic alkalosis and decreased in metabolic acidosis in parallel to secretion of HCO - 3 and K+ ions by the duct epithelium. These findings provide further evidence that the membrane-bound HCO - 3 ATPase is involved in active H+/HCO - 3 transport.

PubMed Disclaimer

References

    1. Hoppe Seylers Z Physiol Chem. 1970 Feb;351(2):184-93 - PubMed
    1. Arch Biochem Biophys. 1954 Jun;50(2):285-98 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2595-9 - PubMed
    1. Pflugers Arch. 1972;333(1):82-94 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1976;292(2):189-92 - PubMed

LinkOut - more resources