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Comment
. 2006 Nov 3;127(3):453-5.
doi: 10.1016/j.cell.2006.10.020.

A mitotic role for BRCA1/BARD1 in tumor suppression?

Paul R Clarke  1 , Helen S Sanderson
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A mitotic role for BRCA1/BARD1 in tumor suppression?

Paul R Clarke et al. Cell. .
Free article

Abstract

The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.

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