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Comment
. 2006 Nov 3;127(3):458-60.
doi: 10.1016/j.cell.2006.10.021.

Asf1, a loveseat for a histone couple

Yunhe Bao  1 , Xuetong Shen
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Asf1, a loveseat for a histone couple

Yunhe Bao et al. Cell. .
Free article

Abstract

In this issue of Cell, English et al. present the first crystal structure of a histone chaperone (Asf1) bound to histones (the H3/H4 heterodimer). The structure provides insights into how histone chaperones participate in nucleosome disassembly. It reveals that Asf1 physically blocks (H3/H4)(2) tetramer formation and that the C terminus of H4 undergoes a dramatic conformational change upon binding to Asf1.

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