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doi: 10.1016/j.cell.2006.10.021.
Asf1, a loveseat for a histone couple
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- PMID: 17081967
- DOI: 10.1016/j.cell.2006.10.021
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Asf1, a loveseat for a histone couple
Cell.
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Abstract
In this issue of Cell, English et al. present the first crystal structure of a histone chaperone (Asf1) bound to histones (the H3/H4 heterodimer). The structure provides insights into how histone chaperones participate in nucleosome disassembly. It reveals that Asf1 physically blocks (H3/H4)(2) tetramer formation and that the C terminus of H4 undergoes a dramatic conformational change upon binding to Asf1.
Comment on
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Structural basis for the histone chaperone activity of Asf1.Cell. 2006 Nov 3;127(3):495-508. doi: 10.1016/j.cell.2006.08.047. Cell. 2006. PMID: 17081973 Free PMC article.
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