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Review
. 2006 Nov;99(11):589-93.
doi: 10.1177/014107680609901122.

The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis

Paolo Zamboni  1
Affiliations
Review

The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis

Paolo Zamboni. J R Soc Med. 2006 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Panel A, classic fibrin cuffs (arrow) thicken veins (v) in a venous ulcer bed, 40 x. Panel B, fibrin cuffs (arrow) encircles proliferated thick walled veins (v) in a peri-ventricular MS plaque, 30 x. Panel A is courtesy of Professor Caggiati, Rome, Italy. Panel B is modified from Adams CW. A Colour Atlas of Multiple Sclerosis. London: Wolfe Med, 1989.
Figure 2
Figure 2
Panel A, intra and extra-cellular iron deposits (ID) encircle a dilated vein (V) in a cerebral MS plaque, Perls' method 150 x. Panel B, intra and extra-cellular iron deposits (ID) encircle a dilated vein (V) in venous ulcer bed, Perls' method 80 x
Figure 3
Figure 3
Panel A, top and bottom: iron-laden macrophages migrated in the cerebral extra-cellular matrix in course of MS, Perls' staining, 200 x. Panel B, top and bottom: iron-laden macrophages migrated in the extra-cellular matrix in course of CVD, Perls' staining, 400 x
Figure 4
Figure 4
Reflux documented in an internal jugular vein under Valsalva in a patient affected by MS. Inversion of the flow wave from positive to negative (i.e. from chest to the head) is well apparent.
See this image and copyright information in PMC

References

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    1. Zamboni P, Scapoli G, Lanzara V, et al. Serum iron and MMP-9 variations in limbs affected by chronic venous disease and venous leg ulcers. Dermatol Surg 2005;31: 644-9 - PubMed
    1. Zamboni P, Izzo M, Tognazzo S, et al. The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis. Free Radic Biol Med 2006;40: 1869-73 - PubMed

Publication types