Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Apr 15;176(1):45-51.
doi: 10.1016/0006-291x(91)90887-d.

Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth

K Matsumoto  1 , H Tajima, T Nakamura
Affiliations

Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth

K Matsumoto et al. Biochem Biophys Res Commun. .

Abstract

Hepatocyte growth factor (HGF) is a potent mitogen for adult rat hepatocytes in primary culture. HGF stimulates growth and DNA synthesis of normal human epidermal melanocytes in culture. The maximal stimulation of DNA synthesis by 4.0-fold occurred with 10 ng/ml HGF. This stimulatory effect was additive with both acidic and basic fibroblast growth factors, while it was inhibited by transforming growth factor-beta 1. Melanocytes expressed a single class of specific, high-affinity receptors for HGF with a Kd of 22 pM and approximately 120 receptors/cell. Thus, HGF is a potent mitogen for normal human epidermal melanocytes.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources