Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Oct;81(1):101-16.

Intralysosomal formation of amyloid fibrils

Intralysosomal formation of amyloid fibrils

T Shirahama et al. Am J Pathol. 1975 Oct.

Abstract

Unusual inclusions, which occurred in the reticuloendothelial cells intimately associated with fresh amyloid deposits, were analyzed by electron microscopy. The inclusions were located in the areas rich in the primary lysosome type of dense bodies and the cytoplasmic invaginations containing well-oriented amyloid fibrils. They were single-membrane-bounded, measured 0.3 to 0.8 mu in width and 0.5 to several microns in length, and showed considerable variation in the electron density of their contents. The latter consisted of two different ultrastructural elements: fibrillar profiles and a homogeneous or finely granular electron-dense substance. The fibrillar profiles were virtually identical in ulstrastructure to the amyloid fibrils and were well-oriented parallel to the long axis of the inclusion. The homogeneous or finely granular electron-dense substance appeared to be comparable to that composing the dense body matrix. The inclusions were usually acid phosphatase positive, but did not take up intravenously injected Thorotrast particles. These data led us to conclude that these inclusions were transitional forms from the usual dense bodies to the deep cytoplasmic invaginations containing well-oriented amyloid fibrils (which are accepted by most investigators as the sites of amyloid formation) and thus constitute direct evidence for the involvement of lysosomes in amyloid fibril formation.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Biophys Biochem Cytol. 1961 Feb;9:409-14 - PubMed
    1. J Lab Clin Med. 1974 Jul;84(1):107-10 - PubMed
    1. Adv Immunol. 1972;15:249-304 - PubMed
    1. J Immunol. 1973 Jan;110(1):21-30 - PubMed
    1. Am J Pathol. 1972 Aug;68(2):441-4 - PubMed

Publication types

LinkOut - more resources