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. 2007 Jan 15;17(2):390-3.
doi: 10.1016/j.bmcl.2006.10.039. Epub 2006 Oct 19.

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity

Gerhard Puerstinger  1 , Jan Paeshuyse, Erik De Clercq, Johan Neyts
Affiliations

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity

Gerhard Puerstinger et al. Bioorg Med Chem Lett. .

Abstract

A novel class of inhibitors of the hepatitis C virus [substituted 2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridines] is described. Introduction of a fluorine in position 2 of the 2-phenyl substituent of the lead anti-pestivirus compound 1 (5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine) resulted in an analogue with selective activity against HCV in the subgenomic replicon system.

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